References:

1. Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-74.

2. Reichelt A, Förster KK, Fischer M, et al. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. Arzneimittelforschung 1994;44:75-80.

3. Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: a placebo¬controlled double¬blind investigation. Clin Ther 1980;3:260-72.

4. Vaz AL. Double¬blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in out¬patients. Curr Med Res Opin 1982;8:145-9.

5. Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7(2):110-4.

6. Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother 2005;39:1080-7.

7. Reginster JY, et al. The long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-6.

8. Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39-46.

9. Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37-8.

10. Bucsi L, Poór G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31-6.

11. Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25-30.

12. Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608-38.

13. Bazières B, Loyau G, Menkès CJ, et al. Le chondroïtine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Ostéoartic 1992;59:466-72 [in French].

14. Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Hüft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69-75 [in German].

15. L'Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77-82 [in German].

16. Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.

17. Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609-14.

18. van der Merwe, M. et al. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Streneous Exercise. Journal of Sports Medicine, vol 2016, Article ID 7498359.

19. Peel S. et al. The Effects of MSM Supplementation on Knee Kinetics during Running, Muscle Strength, and Muscle Soreness following Eccentric Exercise- Induced Quadriceps Damage. Presented at American Society for Biomechanics Conference Aug, 2015 At Columbus, OH.

20. Withee. et al. Effects of MSM on exercise-induced muscle and joint pain: a pilot study. Journal of the International Society of Sports Nutrition. 2015.

21. Kalman D. et al. A Randomized Double Blind Placebo Controlled Evaluation of MSM for Exercise Induced Discomfort/Pain. FASEB J, 2013, 27:1076.7.

22. Kalman D. et al. Influence of MSM on Markers of Exercise Recovery and Performance and Total Antioxidant Capacity. J. of Int. Society of Sports Nut. 2012, 9:46.

23. Debbi et al. Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of the Knee: A Randomized Controlled Study. BMC Comp and Alt Med 2011, 11:50.

24. Ezaki et al. Assessment of Safety and Efficacy of MSM on Bone and Knee Joints in OA Animal Model. J Bone Miner Metab. 2013 Jan;31(1):16-25. doi: 10.1007/ s00774-012-0378-9. Epub 2012 Aug 10.

25. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. P. R. Usha, M. U. R. Naidu Clin Drug Investig. 2004; 24(6): 353–363.

26. Anthonavage, M. et al. Effects of Oral Supplementation With Methylsulfonylmethane on Skin Health and Wrinkle Reduction. Natural Medicine Journal. 2015.

27. Jiang J.X. et al., 2014, Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro FOOD Industry Hi Tech 25: 19-23.

28. Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, 14:291-301. doi: 10.1111/jocd.12174.

29. Oe M, Tashiro T, Yoshida H, et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal. 2015;15:11. doi:10.1186/s12937-016-0128-2.

30. Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. Jensen GS, Attridge VL, Lenninger MR, Benson KF J Med Food. 2015 Jan; 18(1):95-101.

31. Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutrition Journal. 2014;13:70. doi:10.1186/1475-2891-13-70.

32. Rathakrishnan C, Tiku K, Raghavan A, Tiku ML. Release of oxygen radicals by articular chondrocytes: a study of luminol-dependent chemoluminescence and hydrogen peroxide secretion.J Bone Miner Res. 1992;7:1139-48.

33. Henrotin Y, Deby-Dupont G, Deby C, De Bruyn M, Lamy M, Franchimont P. Production of active oxygen species by isolated human chondrocytes. Br J Rheumatol. 1993;32:562-7.

34. Greenwald RA, Moy WW. Inhibition of collagen gelation by action of the superoxide radical. Arthritis Rheum.1979;22:251-9.

35. McCord JM. Free radicals and inflammation: protection of synovial fluid by superoxide dismutase. Science. 1974;185:529-31.

36. McAlindonTE, Jacques P, Zhang Y, Hannan MT, Aliabadi P, Weissman B,et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum. 1996;39:648-56.

37. Goyera, N., Galey, I. and Bernard, B.A. (1998), Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International Journal of Cosmetic Science, 20: 151–158. doi:10.1046/j.1467-2494.1998.171747.